Are the events from ‘The Last of us’ really possible?

In the popular TV series ‘The Last of Us,’ a deadly fungal disease wreaks havoc on humanity, turning people into blood-thirsty creatures. While the show captivates audiences with its gripping storyline, many wonder if such a scenario could actually happen in real life. In this article, we will delve into the science behind the fictional disease and explore the possibilities of a fungal pandemic. Join us as we separate fact from fiction and uncover the truth about medical technology and its potential threats.

The Fungus Threat: Examining the Realities

Unlikely Jump to Humans

In ‘The Last of Us,’ the disease is caused by a fictional fungus called Ophiocordyceps unilateralis, which has the ability to control and zombify insects. While this concept is intriguing, experts state that it is highly unlikely for such a fungus to jump from insects to humans. Joao Araujo, an assistant curator of Mycology at the New York Botanical Garden, explains that the vast differences between human and insect biology make it implausible for this disease to affect humans. Additionally, fungi have not been able to establish themselves in mammals or non-insect animals.

Real-Life Fungal Infections

Although the events of ‘The Last of Us’ may be fictional, it is important to recognize that there are real-world fungal infections that pose a threat to humans. Professor Elaine Bignell, a leading researcher in human fungal pathogens, highlights that numerous fungi infect human brains with devastating outcomes. Diseases caused by fungi such as Aspergillus fumigatus, Candida species, and Cryptococcosis neoformans can lead to chronic and acute lung disease, bloodstream infections, pneumonia, and meningitis.

Mind-Altering Fungi

While the mind-controlling aspects of the fungal infection in ‘The Last of Us’ may be exaggerated, there are examples of fungi that can alter human behavior. Psilocybin, found in magic mushrooms, and ergot, which is associated with hallucinogenic properties, are known to affect human perception and consciousness. However, it is important to note that these fungi do not have the ability to control and manipulate behavior to the extent portrayed in the show.

The Possibility of a Fungal Pandemic

Rising Concerns and Real-Life Threats

Although the events depicted in ‘The Last of Us’ may be fictional, experts are increasingly concerned about the rise of fungal infections worldwide. The World Health Organization (WHO) has identified several high-risk fungi, including Aspergillus fumigatus, Candida species, and Cryptococcosis neoformans. These infections can cause severe illness and even death, particularly in immunocompromised individuals. The public’s lack of awareness about these fungal infections highlights the need for increased research and prevention strategies.

Adaptation and Super-Pathogens

As global temperatures rise, some experts speculate that fungi could potentially evolve and adapt to survive at higher temperatures, posing a greater threat to human health. However, the evolution required for a fungus like Ophiocordyceps unilateralis to infect and control humans would require extensive evolutionary changes. Tom Chiller, chief of the fungal disease branch at the US Centers for Disease Control and Prevention, acknowledges the possibility of more fungi emerging as human pathogens but emphasizes the challenges they would face in terms of treatment and infectivity.

The Role of Medical Technology

In the face of a potential fungal pandemic, medical technology plays a crucial role in both prevention and treatment. Diagnostic tools can help identify fungal infections early, enabling prompt intervention and reducing the risk of complications. Antifungal drugs are essential for treating these infections, but the rise of drug-resistant strains poses a significant challenge. Medical technology advancements are needed to develop new antifungal medications and combat the growing threat of drug resistance.

The Importance of Research and Preparedness

To effectively respond to a potential fungal pandemic, robust research, and preparedness are essential. Understanding the biology and behavior of fungi, identifying high-risk species, and developing strategies for prevention and treatment are key areas of focus. Collaboration between scientists, healthcare professionals, and policymakers is crucial to enhance surveillance, strengthen healthcare systems, and promote public awareness about the risks associated with fungal infections.

A Balance of Realism and Fiction

While the events depicted in ‘The Last of Us’ may be fictional, they bring attention to the potential threats posed by fungal infections. While a scenario like the one portrayed in the show is highly unlikely, real-world fungal infections do exist and require ongoing research and vigilance. Medical technology, combined with scientific advancements and preparedness measures, plays a vital role in mitigating the risks associated with fungal diseases. As we navigate the intersection of science and fiction, it is crucial to separate fact from fiction and remain vigilant in our efforts to address emerging health threats.